Applescript to toggle picture-in-picture globally - I assign this to a keyboard shortcut with better touch tool (cmd+ctrl+p). Make sure "Developer > Allow JavaScript from Apple Events" is enabled in Safari. Download BTT preset -> https://share.folivora.ai/sP/3dd264e3-5d16-425f-8ab3-ce14877ec04f

toggle-pip.applescript

(* 
Description: Applescript to open/close picture-in-picture in Safari
Supported Applications: Safari, IINA
Author: Daniel Rotärmel
Source: https://gist.github.com/danielrotaermel/201f549d5755ea886eb78bb660133722
Instructions: 
   Assign this to a global keyboard shortcut with better touch tool / hammerspoon etc. - suggested: cmd+ctrl+p. 
   Make sure "Developer > Allow JavaScript from Apple Events" is enabled in Safari. 
   Download the BTT preset here -> https://share.folivora.ai/sP/3dd264e3-5d16-425f-8ab3-ce14877ec04f
*)

set jsStartPip to "document.querySelector('video').webkitSetPresentationMode('picture-in-picture')"

set jsVideoExistsAndInline to "document.querySelector('video') !== null ? (document.querySelector('video').webkitPresentationMode === 'inline' ? 'true' : 'false') : 'false';"

on closePip()
	tell application "System Events"
		if exists (window 1 of process "PIPAgent") then
			-- display dialog "Found window 1"
			-- get every UI element of (window 1 of process "PIPAgent")
			click button 3 of (window 1 of process "PIPAgent")
			-- click button 1 of (window 1 of process "PIPAgent")		
		end if
	end tell
end closePip

-- tell application "Safari" to activate
-- tell application "IINA" to activate


tell application "System Events" to set frontApp to name of first process whose frontmost is true

if frontApp = "Safari" then
	tell application "Safari"
		set isVideoInline to do JavaScript jsVideoExistsAndInline in front document
		if isVideoInline is "true" then
			do JavaScript jsStartPip in front document
		else
			tell application "System Events"
				if exists (window 1 of process "PIPAgent") then
					-- display dialog "Found window 1"
					-- get every UI element of (window 1 of process "PIPAgent")
					click button 3 of (window 1 of process "PIPAgent")
					-- click button 1 of (window 1 of process "PIPAgent")		
				end if
			end tell
		end if
	end tell
else if (frontApp = "IINA") then
	tell application "System Events"
		tell process "IINA"
			try
				click menu item "Enter Picture-in-Picture" of menu "Video" of menu bar 1
			on error
				click menu item "Exit Picture-in-Picture" of menu "Video" of menu bar 1
			end try
		end tell
	end tell
else
	closePip()
end if

Just updated the script and btt preset to work with macOS Sonoma